Spyre Therapeutics Ownership | Who Owns Spyre Therapeutics?

Spyre Therapeutics Ownership Summary

Spyre Therapeutics is owned by 99.80% institutional investors, 8.98% insiders. Fmr is the largest institutional shareholder, holding 17.29% of SYRE shares.

SYRE Ownership Benchmark

Type	Name	% Inst	% Insiders	% Retail
Stock	Spyre Therapeutics	99.80%	8.98%	-8.78%
Sector	Healthcare Stocks	57.39%	9.93%	32.68%
Industry	Biotech Stocks	68.48%	9.65%	21.87%

Institutional Shareholders

Top Institutional Shareholders by Total Shares

Holder	Shares	% Holding	Value
Fmr	8.80M	17.29%	$204.89M
Fairmount funds management	4.02M	7.90%	$93.54M
Rtw investments, lp	3.26M	7.19%	$95.83M
Blackrock funding, inc. /de	3.40M	6.68%	$79.14M
Vanguard group	2.85M	5.59%	$66.27M
Vr adviser	2.69M	5.28%	$62.52M
Braidwell lp	2.58M	5.07%	$60.03M
Perceptive advisors	2.57M	5.06%	$59.94M
Commodore capital lp	1.99M	3.91%	$46.28M
Wellington management group llp	1.60M	3.15%	$37.35M

Top Institutional Shareholders by % of Total Assets

Holder	Shares	% Assets	Value
Fairmount funds management	4.02M	9.30%	$93.54M
Vr adviser	2.69M	4.29%	$62.52M
Commodore capital lp	1.99M	3.39%	$46.28M
Affinity asset advisors	824.33K	2.57%	$19.19M
Braidwell lp	2.58M	1.78%	$60.03M
Perceptive advisors	2.57M	1.65%	$59.94M
Rtw investments, lp	3.26M	1.39%	$95.83M
Logos global management lp	500.00K	1.36%	$11.64M
Paradigm biocapital advisors lp	1.53M	1.24%	$35.55M
Boxer capital	696.48K	1.01%	$20.48M

Top Buyers

Holder	Shares	% Assets	Change
Fmr	8.80M	0.01%	1.18M
Jefferies financial group	1.22M	0.17%	762.15K
Blackrock funding, inc. /de	3.40M	0.00%	736.44K
Goldman sachs group	747.55K	0.00%	578.24K
Deerfield management company, l.p. (series c)	450.00K	0.20%	450.00K

Top Sellers

Holder	Shares	% Assets	Change
Assenagon asset management	22.65K	0.00%	-1.12M
Deep track capital, lp	219.01K	0.19%	-780.99K
Farallon capital management	-	-	-666.00K
Avoro capital advisors	-	-	-598.60K
First turn management	-	-	-464.44K

New Positions

Holder	Shares	% Assets	Change	Value
Deerfield management company, l.p. (series c)	450.00K	0.20%	450.00K	$10.48M
Capital world investors	378.57K	0.00%	378.57K	$8.81M
Siren	374.00K	0.38%	374.00K	$8.71M
Victory capital management	268.08K	0.01%	268.08K	$6.24M
Millennium management	167.80K	0.00%	167.80K	$3.91M

Sold Out

Holder	Change
National bank of canada /fi/	-1.00
Gamma investing	-5.00
Us bancorp \de\	-9.00
True wealth design	-16.00
Lindbrook capital	-19.00

Institutional Ownership Trends

Date	Holdings	Change %	Shares	Change %	Ownership	Change %	Increased Position	Change %	Decreased Position	Change %
Dec 31, 2024	120	-	50,788,525	-1.15%	99	0.78%	86	19.44%	18	-25.00%
Sep 30, 2024	55	-49.07%	19,042,524	-62.21%	42	0.34%	42	-44.00%	5	-70.59%
Mar 31, 2024	102	82.14%	31,642,952	12.97%	86	0.27%	74	68.18%	15	200.00%
Dec 31, 2023	56	93.10%	28,010,908	759.76%	179	3.12%	44	62.96%	5	-
Sep 30, 2023	29	-	3,257,983	-	75	-	27	-	-	-

Recent Insider Transactions

Date	Name	Role	Activity	Value
Nov 06, 2024	Albers Jeffrey W.	-	Sell	$246.31K
Oct 25, 2024	Albers Jeffrey W.	-	Sell	$10.93K
Sep 03, 2024	Burrows Scott L	Chief Financial Officer	Sell	$522.07K

Insider Transactions Trends

Date	Buy	Sell
2025 Q1	-	-
2024 Q4	-	2
2024 Q3	-	1
2024 Q2	-	-
2024 Q1	-	-

SYRE Ownership FAQ

Who Owns Spyre Therapeutics?

Spyre Therapeutics shareholders are primarily institutional investors at 99.80%, followed by 8.98% insiders and -8.78% retail investors. The average institutional ownership in Spyre Therapeutics's industry, Biotech Stocks , is 68.48%, which Spyre Therapeutics exceeds.

Who owns the most shares of Spyre Therapeutics?

Spyre Therapeutics’s largest shareholders are Fmr (8.8M shares, 17.29%), Fairmount funds management (4.02M shares, 7.90%), and Rtw investments, lp (3.26M shares, 7.19%). Together, they hold 32.38% of Spyre Therapeutics’s total shares outstanding.

Does Blackrock own Spyre Therapeutics?

BlackRock is not among the top 10 institutional shareholders of Spyre Therapeutics.

Who is Spyre Therapeutics’s biggest shareholder by percentage of total assets invested?

Fairmount funds management is Spyre Therapeutics’s biggest shareholder by percentage of total assets invested, with 9.30% of its assets in 4.02M Spyre Therapeutics shares, valued at 93.54M$.

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